Guanethidine (sulfate)
Product Specifications
UNSPSC Description
Guanethidine sulfate (Guanethidine monosulfate), an antihypertensive agent, is an adrenergic neurone blocking agent. Guanethidine sulfate enters noradrenergic nerve terminals by the neuronal amine carrier[1][2].
Target Antigen
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Guanethidine-sulfate.html
Purity
98.0
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
NC(NCCN1CCCCCCC1)=N.O=S(O)(O)=O
Molecular Weight
296.39
References & Citations
[1]Mitchell JR, et al. Antagonism of the antihypertensive action of guanethidine sulfate by desipramine hydrochloride. JAMA. 1967 Dec 4;202(10):973-6.|[2]Nielsen GD. Guanethidine induced sympathectomy in the adult rat. I. Functional effects following subacute administration. Acta Pharmacol Toxicol (Copenh). 1977 Sep;41(3):203-8.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-B0800/Guanethidine-sulfate-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-B0800/Guanethidine-sulfate-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
645-43-2
Available Sizes
Curated Selection
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