Guanethidine (sulfate)

Guanethidine sulfate (Guanethidine monosulfate), an antihypertensive agent, is an adrenergic neurone blocking agent. Guanethidine sulfate enters noradrenergic nerve terminals by the neuronal amine carrier[1][2].

Product Specifications

CAS Number

[645-43-2]

Product Name Alternative

Guanethidine monosulfate

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Guanethidine-sulfate.html

Purity

98.0

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

NC(NCCN1CCCCCCC1)=N.O=S(O)(O)=O

Molecular Formula

C10H24N4O4S

Molecular Weight

296.39

Precautions

H302, H315, H319, H335

References & Citations

[1]Mitchell JR, et al. Antagonism of the antihypertensive action of guanethidine sulfate by desipramine hydrochloride. JAMA. 1967 Dec 4;202 (10) :973-6.|[2]Nielsen GD. Guanethidine induced sympathectomy in the adult rat. I. Functional effects following subacute administration. Acta Pharmacol Toxicol (Copenh) . 1977 Sep;41 (3) :203-8.