SERT-IN-2
Product Specifications
UNSPSC Description
SERT-IN-2 is a potent SERT inhibitor (IC50=0.58 nM) with promising anti-depression efficacy. SERT-IN-2 shows good bioavailability of 83.28% in rats. SERT-IN-2 can cross the blood-brain barrier[1].
Target Antigen
Serotonin Transporter
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sert-in-2.html
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
N#CC1=CC2=C(NC=C2CCCN3CCN(CC3)C4=NC=C(C5=CC=C(C=C5F)F)C=N4)C=C1
Molecular Weight
458.51
References & Citations
[1]Wang ZZ, et al. Deciphering Nonbioavailable Substructures Improves the Bioavailability of Antidepressants by Serotonin Transporter. J Med Chem. 2023 Jan 12;66(1):371-383.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-148565/SERT-IN-2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-148565/SERT-IN-2-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2055228-33-4
Available Sizes
Curated Selection
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