SERT-IN-2

SERT-IN-2 is a potent SERT inhibitor (IC50=0.58 nM) with promising anti-depression efficacy. SERT-IN-2 shows good bioavailability of 83.28% in rats. SERT-IN-2 can cross the blood-brain barrier[1].

Product Specifications

CAS Number

[2055228-33-4]

UNSPSC

12352005

Target

Serotonin Transporter

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/sert-in-2.html

Purity

98.06

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

N#CC1=CC2=C(NC=C2CCCN3CCN(CC3)C4=NC=C(C5=CC=C(C=C5F)F)C=N4)C=C1

Molecular Formula

C26H24F2N6

Molecular Weight

458.51

References & Citations

[1]Wang ZZ, et al. Deciphering Nonbioavailable Substructures Improves the Bioavailability of Antidepressants by Serotonin Transporter. J Med Chem. 2023 Jan 12;66 (1) :371-383.