Karacoline

Karacoline, a diterpene alkaloid found in the plant Aconitum kusnezoffii, reduces degradation of the extracellular matrix (ECM) in intervertebral disc degeneration (IDD) via the NF-κB signaling pathway[1].

Product Specifications

CAS Number

[39089-30-0]

UNSPSC

12352005

Target

NF-κB

Type

Natural Products

Related Pathways

NF-κB

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/karacoline.html

Purity

99.0

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O[C@@H]1C23C4C([C@]5(O)[C@]6([H])[C@@]3([H])C[C@@]([C@@H](OC)C5)([H])[C@@H]6O)C[C@]2([H])[C@@](CN4CC)(C)CC1

Molecular Formula

C22H35NO4

Molecular Weight

377.52

References & Citations

[1]Owens MJ, et al. Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. J Pharmacol Exp Ther. 1997 Dec;283 (3) :1305-22. PMID: 9400006.. . .|[2]Zhou X, Hong Y, Zhan Y. Karacoline, identified by network pharmacology, reduces degradation of the extracellular matrix in intervertebral disc degeneration via the NF-κB signaling pathway. J Pharm Anal. 2020;10 (1) :13-22.