SZU-B6

SZU-B6 is a PROTAC degrader for SIRT6 with DC50 of 45 nM and 154 nM in cell SK-HEP-1 and Huh-7. SZU-B6 inhibits the proliferation of cell SK-HEP-1 with an IC50 of 1.51 μM, inhibits the colony formation of SK-HEP-1 and Huh-7, induces apoptosis and arrests the cell cycle at G2/M phase in SK-HEP-1. SZU-B6 exhibits antitumor efficacy in mouse model. (Pink: ligand for target protein (HY-16605) ; Black: linker (HY-W012935) ; BLue: ligand for E3 ligase (HY-W453548) [1]

Product Specifications

CAS Number

[3059333-98-8]

UNSPSC

12352211

Target

Apoptosis; PROTACs; Sirtuin

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/szu-b6.html

Purity

98.78

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

NC1=C([N+]([O-])=O)C=CC(N2CCN(CC3CCN(C4=CC5=C(C(N(C6C(NC(CC6)=O)=O)C5=O)=O)C=C4F)CC3)CC2)=C1

Molecular Formula

C29H32FN7O6

Molecular Weight

593.61

References & Citations

[1]Huang J, et al., Discovery of Novel PROTAC SIRT6 Degraders with Potent Efficacy against Hepatocellular Carcinoma. J Med Chem. 2024 Oct 10;67 (19) :17319-17349.