PCAF-IN-2

PCAF-IN-2 (compound 17) is a potent PCAF inhibitor with an IC50 value of 5.31 μM. PCAF-IN-2 shows anti-tumour activity. CAF-IN-2 induces apoptosis and arrest the cell cycle at the G2/M phase[1].

Product Specifications

CAS Number

[56173-05-8]

UNSPSC

12352005

Target

Apoptosis; Histone Acetyltransferase

Type

Reference compound

Related Pathways

Apoptosis; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pcaf-in-2.html

Purity

98.0

Solubility

DMSO : 8.33 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

FC(C1=NN=C2N1N=C(NN)C3=C2C=CC=C3)(F)F

Molecular Formula

C10H7F3N6

Molecular Weight

268.20

References & Citations

[1]Turky A, et al. Design, synthesis, and antitumor activity of novel compounds based on 1,2,4-triazolophthalazine scaffold: Apoptosis-inductive and PCAF-inhibitory effects. Bioorg Chem. 2020 Aug;101:104019.