OR-1896

OR-1896 is an active long-lived metabolite of Levosimendan. OR-1896 is a highly selective phosphodiesterase (PDE) III isoform inhibitor and a powerful vasodilator. OR-1896 can open ATP-sensitive K+ channels and has Ca2+-sensitizing effect. OR-1896 mitigates cardiomyocyte apoptosis, cardiac remodeling and myocardial inflammation[1].

Product Specifications

CAS Number

[220246-81-1]

UNSPSC

12352005

Target

Apoptosis; Drug Metabolite; Phosphodiesterase (PDE) ; Potassium Channel

Type

Reference compound

Related Pathways

Apoptosis; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/or-1896.html

Purity

99.04

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

CC(NC1=CC=C(C([C@H](C)C2)=NNC2=O)C=C1)=O

Molecular Formula

C13H15N3O2

Molecular Weight

245.28

References & Citations

[1]Papp, Z, et al., Levosimendan: molecular mechanisms and clinical implications: consensus of experts on the mechanisms of action of levosimendan. Int J Cardiol. 2012 Aug 23;159 (2) :82-7.