All-trans-retinal
All-trans-retinal is an vitamin A metabolite in the retina, and is produced following photo-isomerization of the visual chromophore 11-cis-Retinal. All-trans-retinal is cleared from photoreceptors by ATP-binding cassette transporter (ABCA4) and all-trans-retinol dehydrogenase (RDH) . All-trans-retinal induces Bax activation via DNA damage to mediate retinal cell apoptosis[1].
Product Specifications
CAS Number
[116-31-4]
UNSPSC
12352211
Hazard Statement
H302, H315
Target
Apoptosis; Endogenous Metabolite
Type
Natural Products
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/All-trans-retinal.html
Purity
99.76
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(/C=C/C=C(/C=C/C1=C(CCCC(C)1C)C)C)=C\C=O
Molecular Formula
C20H28O
Molecular Weight
284.44
Precautions
H302, H315
References & Citations
[1]Sawada O, et al. All-trans-retinal induces Bax activation via DNA damage to mediate retinal cell apoptosis. Exp Eye Res. 2014 Jun;123:27-36.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite
Available Sizes
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