JAK3-IN-7

JAK3-IN-7 is a potent and selective JAK3 inhibitor extracted from patent WO2011013785A1, has an IC50 of <0.01 μM.

JAK

Reference compound

Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt

Cancer-Kinase/protease

Cancer

https://www.medchemexpress.com/1,6-Diazaspiro[3.5]nonane-1-propanenitrile,_3-methyl-_beta_-oxo-6-_7H-pyrrolo[2,3-d]pyrimidin-4-yl_-.html

10 mM in DMSO

N#CCC(N1CC(C)C12CN(C3=C4C(NC=C4)=NC=N3)CCC2)=O

324.38

[1]NOJI, Satoru, et al. NITROGEN-CONTAINING SPIRO-RING COMPOUND AND MEDICINAL USE OF SAME. WO2011013785A1.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-U00390/JAK3-IN-7-DataSheet-MedChemExpress.pdf

http://file.medchemexpress.com/batch_PDF/HY-U00390/

No Development Reported

1263774-57-7