(4E) -SUN9221

(4E) -SUN9221 is a potent antagonist of α1-adrenergic receptor and 5-HT2 receptor, with antihypertensive and anti-platelet aggregation activities.

Product Specifications

CAS Number

[222318-55-0]

UNSPSC

12352005

Target

5-HT Receptor; Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cardiovascular Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/Pyrrolo[2,3-c]azepine-4,8_1H,5H_-dione,_1-[4-[4-_4-fluorobenzoyl_-1-piperidinyl]butyl]-6,7-dihydro-7-methyl-,_4-oxime,__4E_-.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=C/2C=CN1CCCCN3CCC(C(C4=CC=C(F)C=C4)=O)CC3)N(C)CCC2=N/O

Molecular Formula

C25H31FN4O3

Molecular Weight

454.54

References & Citations

[1]Mizuno A, et al. Synthesis and pharmacological evaluation of pyrroloazepine derivatives as potent antihypertensive agents with antiplatelet aggregation activity. Chem Pharm Bull (Tokyo) . 1999 Feb;47 (2) :246-56.