Darodipine

Darodipine (PY 108-068, PY-108068) is a potent calcium channel antagonist.

Product Specifications

CAS Number

[72803-02-2]

Product Name Alternative

PY 108-068; PY-108068

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Calcium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Darodipine.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=C(C)NC(C)=C(C(OCC)=O)C1C2=CC=CC3=NON=C32)OCC

Molecular Formula

C19H21N3O5

Molecular Weight

371.39

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Amenta F, et al. Effect of long-term treatment with the dihydropyridine-type calcium channel blocker darodipine (PY 108-068) on the cerebral capillary network in aged rats. Mech Ageing Dev. 1995 Jan 31;78 (1) :27-37.|[2]Vega JA, et al. Effect of treatment with the dihydropyridine-type calcium antagonist darodipine (PY 108-068) on the expression of neurofilament protein immunoreactivity in the cerebellar cortex of aged rats. Mech Ageing Dev. 1994 Aug;75 (2) :169-77.