SUN 1334H

SUN 1334H is a potent, orally active, highly selective H1 receptor antagonist, with Ki of 9.7 nM.

Product Specifications

CAS Number

[607736-84-5]

UNSPSC

12352005

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Endocrinology

Assay Protocol

https://www.medchemexpress.com/SUN_1334H.html

Purity

95.0

Solubility

10 mM in DMSO

Smiles

O=C(O)COC/C=C/CN1CCN(C(C2=CC=C(F)C=C2)C3=CC=C(F)C=C3)CC1.[H]Cl.[H]Cl

Molecular Formula

C23H28Cl2F2N2O3

Molecular Weight

489.38

References & Citations

[1]Mandhane SN, et al. Preclinical efficacy and safety pharmacology of SUN-1334H, a potent orally active antihistamine agent. Drugs R D. 2008;9 (2) :93-112.|[2]Mandhane SN, et al. Characterization of anti-inflammatory properties and evidence for no sedation liability for the novel antihistamine SUN-1334H. Int Arch Allergy Immunol. 2010;151 (1) :56-69.