CCP peptide

CCP peptide is a synthetic cyclic citrullinated peptide (CCP) and used as the substrate for detecting anti-CCP antibodies serologically. CCP peptide functions as a target for autoantibodies with a very high specificity for rheumatoid arthritis (RA) [1][2].

Product Specifications

CAS Number

[277748-59-1]

UNSPSC

12352209

Target

Others

Type

Peptides

Related Pathways

Others

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ccp-peptide.html

Solubility

10 mM in DMSO

Smiles

C([C@@H]1NC(=O)[C@@H](NC([C@@H](NC([C@H](CC2=CN=CN2)N)=O)CCC(N)=O)=O)CSSC[C@@H](C(NCC(N[C@H](C(N[C@H](C(NCC(N[C@H](C(O)=O)CO)=O)=O)CO)=O)CCCNC(=N)N)=O)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@]([C@@H](C)O)(NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC1=O)[H])C3=CN=CN3

Molecular Formula

C87H145N41O32S2

Molecular Weight

2341.47

References & Citations

[1]Puszczewicz M, et al. Role of anti-citrullinated protein antibodies in diagnosis and prognosis of rheumatoid arthritis. Arch Med Sci. 2011 Apr;7 (2) :189-94.|[2]Söderlin MK, et al. Antibodies against cyclic citrullinated peptide (CCP) and levels of cartilage oligomeric matrix protein (COMP) in very early arthritis: relation to diagnosis and disease activity. Scand J Rheumatol. 2004;33 (3) :185-8.|[3]Schellekens GA, et al. The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide. Arthritis Rheum. 2000 Jan;43 (1) :155-63.