Deoxynivalenol
Product Specifications
UNSPSC Description
Deoxynivalenol, an orally active mycotoxin of the trichothecenes family, crosses the intestinal mucosa by a paracellular pathway through the tight junctions. The Deoxynivalenol transport is not affected by P-glycoprotein (PgP) or multidrug resistance-associated proteins (MRPs) inhibitors[1].
Target Antigen
P-glycoprotein
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/deoxynivalenol.html
Purity
99.39
Solubility
DMSO : 100 mg/mL (ultrasonic)|Ethanol : 30 mg/mL (ultrasonic;warming)
Smiles
O=C(C(C)=C1)[C@@H](O)[C@@]2(CO)[C@]1([H])O[C@]3([H])[C@H](O)C[C@@]2(C)[C@@]34OC4
Molecular Weight
296.32
References & Citations
[1]Sergent T, et al. Deoxynivalenol transport across human intestinal Caco-2 cells and its effects on cellularmetabolism at realistic intestinal concentrations. Toxicol Lett. 2006 Jul 1;164(2):167-76.|[2]Diesing AK, et al. Mycotoxin deoxynivalenol (DON) mediates biphasic cellular response in intestinal porcine epithelial cell lines IPEC-1 and IPEC-J2. Toxicol Lett. 2011 Jan 15;200(1-2):8-18. |[3]Collins TF, et al. Effects of deoxynivalenol (DON, vomitoxin) on in utero development in rats. Food Chem Toxicol. 2006 Jun;44(6):747-57.|[4]Pestka JJ, et al. Immunochemical assessment of deoxynivalenol tissue distribution following oral exposure in the mouse. Toxicol Lett. 2008 May 5;178(2):83-7.|[5]Forsell JH, et al. Comparison of acute toxicities of deoxynivalenol (vomitoxin) and 15-acetyldeoxynivalenol in the B6C3F1 mouse. Food Chem Toxicol. 1987 Feb;25(2):155-62.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N6684/Deoxynivalenol-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N6684/Deoxynivalenol-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
51481-10-8
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS7248559-01 48 Well
Rat Transcription initiation factor TFIID subunit 3 (TAF3) ELISA Kit
Ask
View Details MBS7248559-02 96 Well
Rat Transcription initiation factor TFIID subunit 3 (TAF3) ELISA Kit
Ask
View Details 
MBS7248559-03 5x 96 Well
Rat Transcription initiation factor TFIID subunit 3 (TAF3) ELISA Kit
Ask
View Details