Jionoside A1

Jionoside A1 isolated from Radix Rehmanniae Praeparata displays dose dependent immune-enhancement activity and possesses moderate protective activities on H2O2-treated SH-SY5Y cells[1]. Jionoside A1 has neuroprotective effects and can alleviate the symptoms of ischemic stroke.

Product Specifications

CAS Number

[120444-60-2]

UNSPSC

12352005

Target

Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/jionoside-a1.html

Purity

98.58

Solubility

10 mM in DMSO

Smiles

COC1=C(O)C=CC(/C=C/C(O[C@H]2[C@@H]([C@H]([C@H](OCCC3=CC(O)=C(O)C=C3)O[C@@H]2CO[C@@H]4O[C@@H]([C@@H](O)[C@H](O)[C@H]4O)CO)O)O[C@@]5([H])[C@@H]([C@@H]([C@@H](O)[C@H](C)O5)O)O)=O)=C1

Molecular Formula

C36H48O20

Molecular Weight

800.75

References & Citations

[1]Shen L, et al. Identification of bioactive ingredients with immuno-enhancement and anti-oxidative effects from Fufang-Ejiao-Syrup by LC-MS (n) combined with bioassays. J Pharm Biomed Anal. 2016 Jan 5;117:363-71.|[2]Yu X, Liu X, Mi X, et al. Jionoside A1 alleviates ischemic stroke ischemia/reperfusion injury by promoting Nix-mediated mitophagy. Cell Mol Biol (Noisy-le-grand) . 2023;69 (8) :237-245.