(+) -Catechin hydrate

(+) -Catechin hydrate inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM.

Product Specifications

CAS Number

[225937-10-0]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

COX

Type

Natural Products

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/__addition__-Catechin_hydrate.html

Purity

99.59

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

OC1=CC(O)=C(C[C@H](O)[C@@H](C2=CC=C(O)C(O)=C2)O3)C3=C1.[xH2O]

Molecular Formula

C15H14O6.xH2O

Precautions

H315, H319, H335

References & Citations

[1]Waffo-Téguo P, et al. Potential cancer-chemopreventive activities of wine stilbenoids and flavans extracted from grape (Vitis vinifera) cell cultures. Nutr Cancer. 2001;40 (2) :173-9.|[2]Alshatwi AA. Catechin hydrate suppresses MCF-7 proliferation through TP53/Caspase-mediated apoptosis. J Exp Clin Cancer Res. 2010 Dec 17;29:167.|[3]Cheruku SP, et al. Catechin ameliorates doxorubicin-induced neuronal cytotoxicity in in vitro and episodic memory deficit in in vivo in Wistar rats. Cytotechnology. 2018 Feb;70 (1) :245-259.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Natural Products

Clinical Information

Launched

Isoform

COX-1

Citation 01

Autophagy. 2021 Apr;17 (4) :872-887.|Phytomedicine. 2024 May 12:130:155733.|ACS Omega. 2024 May 17.|Acta Pharm Sin B. 2021 Jan;11 (1) :143-155.|Antioxidants (Basel) . 2024 Jul 28;13 (8) :909.|Biochem Biophys Res Commun. 2018 Sep 3;503 (1) :297-303.|Biochem Biophys Res Commun. 2023 Dec 20:687:149196.|Biomaterials. 2021 Aug:275:120952.|Biomed Chromatogr. 2025 Nov;39 (11) :e70225.|Cancer Rep (Hoboken) . 2025 May;8 (5) :e70169.|Cell Death Dis. 2024 Dec 26;15 (12) :932.|Food Res Int. 2025 Oct:218:116882.|Int J Insect Sci. 2018 Feb 28:10:1179543318758409.|Phytomedicine. 2025 May:140:156549.|Plant Cell Physiol. 2020 Feb 1;61 (2) :318-330.|Plants. 2021 Nov 20;10 (11) :2525.|Rapid Commun Mass Spectrom. 2025 Dec 15;39 (23) :e10134.|SSRN. 2023 Jul 14.|Toxicol Appl Pharmacol. 2024 Jul 14:490:117036.