Clocapramine (dihydrochloride hydrate)

Clocapramine hydrochloride hydrate is an antagonist of the D2 and 5-HT2A receptors.

Product Specifications

CAS Number

[60789-62-0]

Product Name Alternative

3-Chlorocarpipramine (dihydrochloride hydrate)

UNSPSC

12352005

Target

5-HT Receptor; Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Clocapramine_hydrochloride_hydrate.html

Solubility

10 mM in DMSO

Smiles

O=C(C1(N2CCCCC2)CCN(CCCN3C4=CC(Cl)=CC=C4CCC5=CC=CC=C53)CC1)N.Cl.O.Cl

Molecular Formula

C28H41Cl3N4O2

Molecular Weight

572.01

References & Citations

[1]Schotte A, et al. In vitro receptor binding and in vivo receptor occupancy in rat and guinea pig brain: risperidone compared with antipsychotics hitherto used. Jpn J Pharmacol. 1995 Dec;69 (4) :399-412.|[2]Sumiyoshi T, et al. Atypicality of several antipsychotics on the basis of in vivo dopamine-D2 and serotonin-5HT2 receptor occupancy. Neuropsychopharmacology. 1995 Feb;12 (1) :57-64.