Clocapramine (dihydrochloride hydrate)
Clocapramine hydrochloride hydrate is an antagonist of the D2 and 5-HT2A receptors.
Product Specifications
CAS Number
[60789-62-0]
Product Name Alternative
3-Chlorocarpipramine (dihydrochloride hydrate)
UNSPSC
12352005
Target
5-HT Receptor; Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Clocapramine_hydrochloride_hydrate.html
Solubility
10 mM in DMSO
Smiles
O=C(C1(N2CCCCC2)CCN(CCCN3C4=CC(Cl)=CC=C4CCC5=CC=CC=C53)CC1)N.Cl.O.Cl
Molecular Formula
C28H41Cl3N4O2
Molecular Weight
572.01
References & Citations
[1]Schotte A, et al. In vitro receptor binding and in vivo receptor occupancy in rat and guinea pig brain: risperidone compared with antipsychotics hitherto used. Jpn J Pharmacol. 1995 Dec;69 (4) :399-412.|[2]Sumiyoshi T, et al. Atypicality of several antipsychotics on the basis of in vivo dopamine-D2 and serotonin-5HT2 receptor occupancy. Neuropsychopharmacology. 1995 Feb;12 (1) :57-64.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
5-HT2 Receptor; D2 Receptor; α-1 microglobulin
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