Pimethixene

Pimethixene is antihistamine and antiserotonergic compound, acts as an antimigraine agent. Pimethixene is a highly potent antagonist of 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as well as muscarinic M1 and M2 receptors, with pKis of 7.63, 10.22, 10.44, 8.42, 10.14, 8.19, 7.54, 8.61 and 9.38, respectively[1].

Product Specifications

CAS Number

[314-03-4]

Product Name Alternative

Pimetixene

UNSPSC

12352005

Target

5-HT Receptor; Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Neurological Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/Pimethixene.html

Solubility

10 mM in DMSO

Smiles

CN1CC/C(CC1)=C2C3=C(SC4=C\2C=CC=C4)C=CC=C3

Molecular Formula

C19H19NS

Molecular Weight

293.43

References & Citations

[1]Schmitz B, et al. BF-1--a novel selective 5-HT2B receptor antagonist blocking neurogenic dural plasma protein extravasation in guinea pigs. Eur J Pharmacol. 2015 Mar 15;751:73-80.