AZ7550

AZ7550 is an active metabolite of AZD9291 and inhibits the activity of IGF1R with an IC50 of 1.6 μM.

Product Specifications

CAS Number

[1421373-99-0]

UNSPSC

12352005

Hazard Statement

H302-H315-H319

Target

Drug Metabolite; EGFR; IGF-1R

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Endocrinology

Assay Protocol

https://www.medchemexpress.com/AZ7550.html

Purity

97.09

Solubility

DMSO : 83.33 mg/mL (ultrasonic; adjust pH to 5 with 1 M HCL)

Smiles

C=CC(NC1=CC(NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2)=C(OC)C=C1N(C)CCNC)=O

Molecular Formula

C27H31N7O2

Molecular Weight

485.58

Precautions

P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

References & Citations

[1]Finlay MR, et al. Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor. J Med Chem. 2014 Oct 23;57 (20) :8249-67.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 1

Citation 01

Biopharm Drug Dispos. 2023 Apr;44 (2) :165-174.|J Pharm Biomed Anal. 2025 Jan 3:255:116662.|bioRxiv. 2024 Jul 2:2024.06.27.600680.|Patent. US20250275968A1.