Hydroxyzine

Hydroxyzine, a benzodiazepine antihistamine agent, acts as an orally active histamine H1-receptor and serotonin antagonist. Hydroxyzine has anxiolytic effect and can be used for the research of generalised anxiety disorder[1].

Product Specifications

CAS Number

[68-88-2]

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Inflammation/Immunology; Endocrinology

Assay Protocol

https://www.medchemexpress.com/hydroxyzine.html

Concentration

10mM

Purity

99.72

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 5 mg/mL (ultrasonic; warming; adjust pH to 4 with HCl; heat to 60°C)

Smiles

ClC1=CC=C(C(N2CCN(CCOCCO)CC2)C3=CC=CC=C3)C=C1

Molecular Formula

C21H27ClN2O2

Molecular Weight

374.90

Precautions

H315, H319, H320

References & Citations

[1]Minogiannis, P., et al., Hydroxyzine inhibits neurogenic bladder mast cell activation. Int J Immunopharmacol, 1998. 20 (10) : p. 553-63.|[2]Morichi, R. and G. Pepeu, A study of the influence of hydroxyzine and diazepam on morphine antinociceptoion in the rat. Pain, 1979. 7 (2) : p. 173-80.|[3]Nikita Shekhar Sawantdesai, et al. Evaluation of anxiolytic effects of aripiprazole and hydroxyzine as a combination in mice. J Basic Clin Pharm. 2016 Sep;7 (4) :97-104.