Lincomycin (hydrochloride)

Lincomycin hydrochloride is the salt form of the antibiotic lincomycin. Lincomycin can affect the synthesis of protein, RNA and DNA in the mycelium of the lincomycin-producing organism Act. Roseolus. Lincomycin inhibits protein synthesis in gram-positive and - to a lower degree - also in gram-negative bacteria. Lincomycin binds to the 50S subunits of bacterial ribosomes and act on aminoacyl-tRNA binding and the transpeptidation reaction[1][2][3].

Product Specifications

CAS Number

[859-18-7]

Product Name Alternative

U10149A

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Antibiotic; Bacterial; DNA/RNA Synthesis

Type

Natural Products

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/lincomycin-hydrochloride.html

Purity

99.29

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

C[C@@H](O)[C@@]([C@@]([C@@H]([C@H](O)[C@H]1O)O)([H])O[C@@H]1SC)([H])NC([C@@H]2C[C@@H](CCC)CN2C)=O.Cl

Molecular Formula

C18H35ClN2O6S

Molecular Weight

443.00

Precautions

H315, H319, H335

References & Citations

[1]Griaznova, N.S., et al., [Effect of lincomycin and other protein synthesis inhibitors on the metabolism of Actinomyces roseolus, a producer of lincomycin]. Antibiotiki, 1980. 25 (4) : p. 250-6.|[2]Hummel, H., W. Piepersberg, and A. Bock, Analysis of lincomycin resistance mutations in Escherichia coli. Mol Gen Genet, 1979. 169 (3) : p. 345-7.|[3]Champney, W.S. and C.L. Tober, Specific inhibition of 50S ribosomal subunit formation in Staphylococcus aureus cells by 16-membered macrolide, lincosamide, and streptogramin B antibiotics. Curr Microbiol, 2000. 41 (2) : p. 126-35.