Methyldopa (hydrochloride)

Methyldopa hydrochloride (L- (-) -α-Methyldopa hydrochloride) hydrochloride, a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors) . Methyldopa hydrochloride is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system[1][2].

Product Specifications

CAS Number

[884-39-9]

Product Name Alternative

L- (-) -α-Methyldopa (hydrochloride) ; MK-351 (hydrochloride)

UNSPSC

12352005

Target

Adrenergic Receptor; Endogenous Metabolite

Type

Reference compound

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cardiovascular Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/l-_-_-_alpha_-methyldopa-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

OC1=C(O)C=CC(C[C@@](C)(C(O)=O)N)=C1.Cl

Molecular Formula

C10H14ClNO4

Molecular Weight

247.68

References & Citations

[1]Sweet CS. New centrally acting antihypertensive drugs related to methyldopa and clonidine. Hypertension. 1984;6 (5 Pt 2) :II51-II56.|[2]Fox GR, et al. The effects of phenobarbital, atropine, L-alpha-methyldopa, and DL-propranolol on dieldrin-induced hyperglycemia in the adult rat. Toxicol Appl Pharmacol. 1985;78 (3) :342-350.