RG-12915
Product Specifications
UNSPSC Description
RG-12915 is a selective 5-HT3 antagonist, with IC50 value of 0.16 nM.
Target Antigen
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/RG-12915.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C2OC(CCCC3)C3C2=CC(Cl)=C1)NC4CN5CCC4CC5
Molecular Weight
360.88
References & Citations
[1]Fitzpatrick LR, et al. RG 12915: a potent 5-hydroxytryptamine-3 antagonist that is an orally effective inhibitor of cytotoxic drug-induced emesis in the ferret and dog. J Pharmacol Exp Ther. 1990 Aug;254(2):450-5.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-19110/RG-12915-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-19110/
Clinical Information
Phase 3
CAS Number
136174-04-4
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