PFI-2
Product Specifications
UNSPSC Description
PFI-2 ((R)-PFI-2 hydrochloride) hydrochloride is a potent and selective SET domain containing lysine methyltransferase 7 (SETD7) inhibitor. (R)-PFI-2 shows high inhibiting activity with IC50 value of 2.0??nM and (S)-PFI-2 shows inhibiting activity with IC50 ?value of?1.0??μM. PFI-2 hydrochloride can be used for the research of chronic kidney disease and inflammation response in the development of renal fibrosis[1][2].
Target Antigen
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/PFI-2.html
Solubility
10 mM in DMSO
Smiles
O=S(C1=CC2=C(CNCC2)C(F)=C1)(N[C@H](CC3=CC=CC(C(F)(F)F)=C3)C(N4CCCC4)=O)=O
Molecular Weight
499.52
References & Citations
[1]Yuzhen Niu, et al. Revealing inhibition difference between PFI-2 enantiomers against SETD7 by molecular dynamics simulations, binding free energy calculations and unbinding pathway analysis. Sci Rep. 2017 Apr 18;7:46547.|[2]Benquan Liu, et al. Pharmacological inhibition of SETD7 by PFI-2 attenuates renal fibrosis following folic acid and obstruction injury. Eur J Pharmacol. 2021 Jun 15;901:174097. Acta Pharmacol Sin. 2021 Apr 13.|Biochem Pharmacol. 2023 Dec 2:115964.|Med Oncol. 2023 Apr 12;40(5):146.|Patent. US20180263995A1.|Sci Adv. 2023 May 26;9(21):eade4186.|Sci Total Environ. 2022 Dec 5;861:160682.|Int J Mol Med. 2021 Dec;48(6):210.|Mol Carcinog. 2023 May 5.|Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):2961-2966. |Research Square Print. September 20th, 2022.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-18627/PFI-2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-18627/
Clinical Information
No Development Reported
CAS Number
1627676-59-8
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