Heparin

Heparin is a highly sulfated glycosaminoglycan, that is widely used as an injectable anticoagulant, and has the highest negative charge density of any known biological molecule. Heparin significantly inhibits exosome-cell interactions.

Product Specifications

CAS Number

[9005-49-6]

UNSPSC

12352211

Hazard Statement

H302

Target

Autophagy; Bacterial; Endogenous Metabolite; Thrombin

Type

Natural Products

Related Pathways

Anti-infection; Autophagy; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Cardiovascular Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/Heparin.html

Solubility

H2O : 100 mg/mL

Smiles

O[C@H]1[C@H](O[C@H]2[C@H](OS(O)(=O)=O)[C@@H](O)[C@H](OC)[C@H](C(O)=O)O2)[C@@H](COS(O)(=O)=O)O[C@H](OC)[C@@H]1NS(O)(=O)=O.[n]

Precautions

H302

References & Citations

[1]Capila I, et al. Heparin-protein interactions. Angew Chem Int Ed Engl. 2002 Feb 1;41 (3) :391-412.|[2]Ito M, et al. Inhibitory effect of dextran sulfate and heparin on the replication of human immunodeficiency virus (HIV) in vitro. Antiviral Res. 1987 Jul;7 (6) :361-7.|[3]Ganapathy R, et al. Effect of heparin and fractionated heparin on trophoblast invasion. Hum Reprod. 2007 Sep;22 (9) :2523-7.