I3MT-3

I3MT-3 (HMPSNE) is a potent, selective, and cell-membrane permeable inhibitor of 3-Mercaptopyruvate sulfurtransferase (3MST) (IC50=2.7 μM) . I3MT-3 is inactive for other H2S/sulfane sulfur-producing enzymes. I3MT-3 targets a persulfurated cysteine residue located in the active site of 3MST[1].

Product Specifications

CAS Number

[459420-09-8]

Product Name Alternative

HMPSNE

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Hippo (MST)

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/i3mt-3.html

Concentration

10mM

Purity

99.76

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C1NC(SCC(C2=C3C=CC=CC3=CC=C2)=O)=NC(C)=C1

Molecular Formula

C17H14N2O2S

Molecular Weight

310.37

Precautions

H302, H315, H319, H335

References & Citations

[1]Kenjiro Hanaoka, et al. Discovery and Mechanistic Characterization of Selective Inhibitors of H 2 S-producing Enzyme: 3-Mercaptopyruvate Sulfurtransferase (3MST) Targeting Active-site Cysteine Persulfide. Sci Rep. 2017 Jan 12;7:40227|[2]Fiona Augsburger, et al. Role of 3-Mercaptopyruvate Sulfurtransferase in the Regulation of Proliferation, Migration, and Bioenergetics in Murine Colon Cancer Cells. Biomolecules. 2020 Mar 13;10 (3) :447.