PSI-7409

PSI-7409 is the active 5'-triphosphate metabolite of Sofosbuvir (PSI-7977) . Sofosbuvir (PSI-7977) is a selective and highly active nucleotide analog inhibitor of HCV.

Product Specifications

CAS Number

[1015073-42-3]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

HCV

Type

Reference compound

Related Pathways

Anti-infection

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/PSI-7409.html

Purity

98.03

Solubility

DMF : < 1 mg/mL (ultrasonic; warming; heat to 80°C) |DMSO : < 1 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)

Smiles

O[C@@H]([C@@](C)(F)[C@H](N1C(NC(C=C1)=O)=O)O2)[C@H]2COP(O)(OP(OP(O)(O)=O)(O)=O)=O

Molecular Formula

C10H16FN2O14P3

Molecular Weight

500.16

Precautions

H315, H319, H335

References & Citations

[1]Lam AM, et al. PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication. Antimicrob Agents Chemother. 2010 Aug;54 (8) :3187-96.|[2]Murakami E, et al. Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Citation 01

Antiviral Res. 2020 Mar;175:104708.|Biochem Biophys Res Commun. 2023 Jan 22:641:50-56.|Cell. 2022 Nov 10;185 (23) :4347-4360.e17.|J Virol Methods. 2021 Dec:298:114283.|Microbiol Spectr. 2022 Oct 26;10 (5) :e0272922.|Asian J Pharm Sci. 2021 Nov;16 (6) :772-783.|J Med Chem. 2025 Jun 26;68 (12) :12414-12433.