CP-809101

CP-809101 is a potent and highly selective 5-HT2C receptor agonist, with pEC50s of 9.96, 7.19 and 6.81 M for human 5HT2C, 5HT2B and 5HT2A receptor. CP-809101 inhibits conditioned avoidance responding in rats and antagonizes both PCP (phencyclidine hydrochloride) - and d-amphetamine-induced hyperactivity. CP-809101 also reduces food and nicotine dependence in rats, can be used in studies of antipsychotic and nicotine dependence[1][2].

Product Specifications

CAS Number

[479683-64-2]

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cp-809101.html

Solubility

10 mM in DMSO

Smiles

ClC1=CC(COC2=NC(N3CCNCC3)=CN=C2)=CC=C1

Molecular Formula

C15H17ClN4O

Molecular Weight

304.77

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Siuciak JA, et al. CP-809,101, a selective 5-HT2C agonist, shows activity in animal models of antipsychotic activity. Neuropharmacology. 2007 Feb;52 (2) :279-90. |[2]Higgins GA, et al. Evaluation of chemically diverse 5-HT₂c receptor agonists on behaviours motivated by food and nicotine and on side effect profiles. Psychopharmacology (Berl) . 2013 Apr;226 (3) :475-90.