SBE13

SBE13 is a potent and selective Plk1 inhibitor, with an IC50 of 200 pM; SBE13 poorly inhibits Plk2 (IC50>66 μM) or Plk3 (IC50=875 nM) .

Product Specifications

CAS Number

[775294-82-1]

UNSPSC

12352005

Hazard Statement

H302

Target

Autophagy; Polo-like Kinase (PLK)

Type

Reference compound

Related Pathways

Autophagy; Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/SBE13.html

Solubility

10 mM in DMSO

Smiles

COC1=CC=C(CCNCC2=CC=C(OCC3=CC=C(Cl)N=C3)C(OC)=C2)C=C1OC

Molecular Formula

C24H27ClN2O4

Molecular Weight

442.94

Precautions

P264-P270-P330-P501

References & Citations

[1]Keppner S, et al. Identification and validation of a potent type II inhibitor of inactive polo-like kinase 1. ChemMedChem. 2009 Nov;4 (11) :1806-9.|[2]Keppner S, et al. Fate of primary cells at the G?/S boundary after polo-like kinase 1 inhibition by SBE13. Cell Cycle. 2011 Feb 15;10 (4) :708-20. Epub 2011 Feb 15.|[3]Keppner S, et al. Biological impact of freezing Plk1 in its inactive conformation in cancer cells. Cell Cycle. 2010 Feb 15;9 (4) :761-73. Epub 2010 Feb 16.