Arhalofenate

Arhalofenate (MBX 102) is a selective partial agonist of peroxisome proliferator-activated receptor (PPAR) -γ, used for the treatment of type 2 diabetes.

Product Specifications

CAS Number

[24136-23-0]

Product Name Alternative

MBX 102; JNJ 39659100

UNSPSC

12352005

Hazard Statement

H301-H319-H410

Target

PPAR

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/MBX_102.html

Purity

99.85

Solubility

10 mM in DMSO

Smiles

O=C(OCCNC(C)=O)[C@@H](C1=CC=C(Cl)C=C1)OC2=CC=CC(C(F)(F)F)=C2

Molecular Formula

C19H17ClF3NO4

Molecular Weight

415.79

Precautions

P264-P270-P273-P280-P305+P351+P338-P330-P391-P405-P501

References & Citations

[1]Gregoire FM, et al. MBX-102/JNJ39659100, a novel peroxisome proliferator-activated receptor-ligand with weak transactivation activity retains antidiabetic properties in the absence of weight gain and edema. Mol Endocrinol. 2009 Jul;23 (7) :975-88.|[2]Chandalia A, et al. MBX-102/JNJ39659100, a novel non-TZD selective partial PPAR-γ agonist lowers triglyceride independently of PPAR-α activation. PPAR Res. 2009;2009:706852.