Ziprasidone (hydrochloride)

Ziprasidone (CP-88059) hydrochloride is an orally active combined 5-HT and dopamine receptor antagonist[1]. Ziprasidone hydrochloride has affinities for Rat D2 (Ki=4.8 nM), 5-HT2A (Ki=0.42 nM) and 5-HT1A (Ki=3.4 nM) [1].

Product Specifications

CAS Number

[122883-93-6]

Product Name Alternative

CP-88059 hydrochloride

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

5-HT Receptor; Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ziprasidone-hydrochloride.html

Purity

99.74

Solubility

DMSO : 20 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

ClC1=CC2=C(CC(N2)=O)C=C1CCN(CC3)CCN3C4=NSC5=C4C=CC=C5.Cl

Molecular Formula

C21H22Cl2N4OS

Molecular Weight

449.40

Precautions

H302, H315, H319, H335

References & Citations

[1]Rollema H, et al. 5-HT (1A) receptor activation contributes to ziprasidone-induced dopamine release in the rat prefrontal cortex. Biol Psychiatry. 2000;48 (3) :229-237.|[2]Schmidt AW, et al. Ziprasidone: a novel antipsychotic agent with a unique human receptor binding profile. Eur J Pharmacol. 2001;425 (3) :197-201.|[3]Seeger TF, et al. Ziprasidone (CP-88,059) : a new antipsychotic with combined dopamine and serotonin receptor antagonist activity. J Pharmacol Exp Ther. 1995;275 (1) :101-113.|[4]Park S, et al. The effect of ziprasidone on body weight and energy expenditure in female rats. Metabolism. 2012;61 (6) :787-793.