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AMG 837

AMG 837 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[865231-46-5]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Free Fatty Acid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/AMG-837.html

Purity

98.5900

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC(C[C@H](C#CC)C1=CC=C(C=C1)OCC2=CC=CC(C3=CC=C(C(F)(F)F)C=C3)=C2)=O

Molecular Formula

C26H21F3O3

Molecular Weight

438.44

Precautions

H315, H319, H335

References & Citations

[1]Houze JB, et al. AMG 837: a potent, orally bioavailable GPR40 agonist. Bioorg Med Chem Lett. 2012 Jan 15;22 (2) :1267-70.|[2]Lin DC, et al. AMG 837: a novel GPR40/FFA1 agonist that enhances insulin secretion and lowers glucose levels in rodents. PLoS One. 2011;6 (11) :e27270.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Citation 01

Biomed Pharmacother. 2023 May:161:114509.|Biochem Biophys Res Commun. 2025 Apr 9:757:151624.

Available Sizes

Curated Selection

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