Quinacrine (dihydrochloride)
Product Specifications
UNSPSC Description
Quinacrine (Mepacrine) dihydrochloride is an orally bioavailable antimalarial agent, which possess anticancer effect both in vitro and vivo. Quinacrine dihydrochloride suppresses NF-κB and activate p53 signaling, which results in the induction of the apoptosis[1].
Target Antigen
Apoptosis; Autophagy; Mitophagy; Parasite
Type
Reference compound
Related Pathways
Anti-infection;Apoptosis;Autophagy
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/Quinacrine-dihydrochloride.html
Purity
99.38
Solubility
DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C)|H2O : 13.89 mg/mL (ultrasonic)
Smiles
CC(NC1=C(C=C(OC)C=C2)C2=NC3=CC(Cl)=CC=C31)CCCN(CC)CC.Cl.Cl
Molecular Weight
472.88
References & Citations
[1]Xiaoyang Wu, et al. Quinacrine Inhibits Cell Growth and Induces Apoptosis in Human Gastric Cancer Cell Line SGC-7901. Curr Ther Res Clin Exp. 2012 Feb;73(1-2):52-64.|[2]Anna Eriksson, et al. Towards repositioning of quinacrine for treatment of acute myeloid leukemia - Promising synergies and in vivo effects. Leuk Res. 2017 Dec;63:41-46.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-13735A/Quinacrine-dihydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-13735A/Quinacrine-dihydrochloride-SDS-MedChemExpress.pdf
Clinical Information
Phase 2
CAS Number
69-05-6
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