Vanoxerine
Vanoxerine (GBR-12909) is a competitive, potent, and highly selective dopamine reuptake inhibitor (Ki=1 nM) . Vanoxerine (GBR-12909) binds to the target site on the dopamine transporter (DAT) [1].
Product Specifications
CAS Number
[67469-69-6]
Product Name Alternative
GBR 12909; I893
UNSPSC
12352005
Target
Dopamine Transporter
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/vanoxerine.html
Solubility
10 mM in DMSO
Smiles
FC1=CC=C(C(C2=CC=C(F)C=C2)OCCN3CCN(CCCC4=CC=CC=C4)CC3)C=C1
Molecular Formula
C28H32F2N2O
Molecular Weight
450.56
References & Citations
[1]Rothman RB, et al. Dopamine transport inhibitors based on GBR12909 and benztropine as potential medications to treat cocaine addiction. Biochem Pharmacol. 2008 Jan 1;75 (1) :2-16.|[2]Andersen PH. The dopamine inhibitor GBR 12909: selectivity and molecular mechanism of action. Eur J Pharmacol.|[3]Hirate K, et al. Characteristics of the ambulation-increasing effect of GBR-12909, a selective dopamine uptakeinhibitor, in mice. Jpn J Pharmacol. 1991 Apr;55 (4) :501-11.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3
Citation 01
Biochem Biophys Res Commun. 2020 May 14;525 (4) :989-996.|Cell. 2025 Oct 24:S0092-8674 (25) 01131-6.|Front Cell Neurosci. 2018 Sep 11:12:309.|Neuron. 2023 May 17;111 (10) :1626-1636.e6.|bioRxiv. 2024 Dec 23:2024.12.22.629999.|Nature. 2024 Aug;632 (8025) :686-694.|University of Groningen. 2016 Jun 1.
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