CGS 21680

CGS 21680 is a selective adenosine A2A receptor agonist, with a Ki of 27 nM.

Product Specifications

CAS Number

[120225-54-9]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Adenosine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cgs-21680.html

Solubility

10 mM in DMSO

Smiles

O=C(CCC1=CC=C(C=C1)CCNC2=NC3=C(C(N)=N2)N=CN3[C@H]4[C@@H]([C@@H]([C@H](O4)C(NCC)=O)O)O)O

Molecular Formula

C23H29N7O6

Molecular Weight

499.52

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Bao R, et al. Adenosine and the adenosine A2A receptor agonist, CGS21680, upregulate CD39 and CD73 expression through E2F-1 and CREB in regulatory T cells isolated from septic mice. Int J Mol Med. 2016 Sep;38 (3) :969-75.|[2]Zhang M, et al. Activation of the adenosine A2A receptor exacerbates experimental autoimmune neuritis in Lewis rats in association with enhanced humoral immunity. J Neuroimmunol. 2016 Apr 15;293:129-36.|[3]Melani A, et al. Low doses of the selective adenosine A2A receptor agonist CGS21680 are protective in a rat model of transient cerebral ischemia. Brain Res. 2014 Mar 10;1551:59-72.|[4]Komaki S, et al. Trk and cAMP-dependent survival activity of adenosine A (2A) agonist CGS21680 on rat motoneurons in culture. Neurosci Lett. 2012 Jul 26;522 (1) :21-4.|[5]Rosaria Volpini, et al. Adenosine receptor agonists: synthesis and binding affinity of 2- (aryl) alkylthioadenosine derivatives.