Tasisulam

Tasisulam is a anticancer agent and induces apoptosis via the intrinsic pathway, resulting in cytochrome c release and caspase-dependent cell death. Tasisulam inhibits mitotic progression and induces vascular normalization[1].

Product Specifications

CAS Number

[519055-62-0]

Product Name Alternative

LY 573636

UNSPSC

12352005

Hazard Statement

H315-H317-H319-H335

Target

Apoptosis; Molecular Glues

Type

Reference compound

Related Pathways

Apoptosis; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tasisulam.html

Purity

99.77

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(NS(=O)(C1=CC=C(Br)S1)=O)C2=CC=C(Cl)C=C2Cl

Molecular Formula

C11H6BrCl2NO3S2

Molecular Weight

415.11

Precautions

P261-P264-P271-P272-P280-P302+P352-P304+P340-P305+P351+P338-P362-P403+P233-P405-P501

References & Citations

[1]Meier T, et al. Tasisulam sodium, an antitumor agent that inhibits mitotic progression and induces vascular normalization. Mol Cancer Ther. 2011 Nov;10 (11) :2168-78.