TCS 2314
TCS 2314 (compound 3) is orally active and selective very late antigen-4 (VLA-4, α4β1, CD49d/CD29) antagonist with an IC50 of 4.4 nM[1].
Product Specifications
CAS Number
[317353-73-4]
UNSPSC
12352005
Target
Integrin
Type
Reference compound
Related Pathways
Cytoskeleton
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tcs-2314.html
Purity
99.0
Solubility
10 mM in DMSO
Smiles
O=C(O)CC1CCN(C([C@H]2N(C(CC3=CC=C(NC(NC4=CC=CC=C4C)=O)C=C3)=O)CCOC2)=O)CC1
Molecular Formula
C28H34N4O6
Molecular Weight
522.59
References & Citations
[1]Muro F, et al. Discovery of trans-4-[1-[[2,5-Dichloro-4- (1-methyl-3-indolylcarboxamido) phenyl]acetyl]- (4S) -methoxy- (2S) -pyrrolidinylmethoxy]cyclohexanecarboxylic acid: an orally active, selective very late antigen-4 antagonist. J Med Chem. 2009 Dec 24;52 (24) :7974-92.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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