SEL120-34A
Product Specifications
UNSPSC Description
SEL120-34A is a potent, selective, orally available, ATP-competitive CDK8 inhibitor, with IC50s of 4.4 nM and 10.4 nM for CDK8/CycC and CDK19/CycC, respectively, with antitumor activity.
Target Antigen
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/CDK8-IN-2.html
Solubility
10 mM in DMSO
Smiles
CC1=C2C3=C(C(Br)=C1Br)CCCN3C(N4CCNCC4)=N2
Molecular Weight
414.14
References & Citations
[1]Rzymski T, et al. SEL120-34A is a novel CDK8 inhibitor active in AML cells with high levels of serine phosphorylation of STAT1 and STAT5 transactivation domains. Oncotarget. 2017 May 16;8(20):33779-33795.Friedrich-Alexander-Universität Erlangen-Nürnberg. 2023 Jun 23.|Nat Commun. 2024 Mar 19;15(1):2198.|Nat Commun. 2019 Oct 18;10(1):4741. |Cell. 2021 Apr 15;184(8):2167-2182.e22.|Int J Mol Sci. 2022 Feb 24;23(5):2493.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-111388/SEL120-34A-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-111388/
Clinical Information
No Development Reported
CAS Number
1609522-33-9
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