Romaciclib
SEL120-34A is a potent, selective, orally available, ATP-competitive CDK8 inhibitor, with IC50s of 4.4 nM and 10.4 nM for CDK8/CycC and CDK19/CycC, respectively, with antitumor activity.
Product Specifications
CAS Number
[1609522-33-9]
Product Name Alternative
SEL120-34A
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/CDK8-IN-2.html
Purity
99.49
Solubility
10 mM in DMSO
Smiles
CC1=C2C3=C(C(Br)=C1Br)CCCN3C(N4CCNCC4)=N2
Molecular Formula
C15H18Br2N4
Molecular Weight
414.14
References & Citations
[1]Rzymski T, et al. SEL120-34A is a novel CDK8 inhibitor active in AML cells with high levels of serine phosphorylation of STAT1 and STAT5 transactivation domains. Oncotarget. 2017 May 16;8 (20) :33779-33795.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK19; CDK8; CDK9
Citation 01
Friedrich-Alexander-Universität Erlangen-Nürnberg. 2023 Jun 23.|Nat Commun. 2024 Mar 19;15 (1) :2198.|Nat Commun. 2019 Oct 18;10 (1) :4741. |Adv Sci (Weinh) . 2025 Nov 19:e18346.|bioRxiv. 2025 January 24.|Cell. 2021 Apr 15;184 (8) :2167-2182.e22.|Int J Mol Sci. 2022 Feb 24;23 (5) :2493.
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