UCN-02

UCN-02 (7-epi-Hydroxystaurosporine) is a selective protein kinase C (PKC) inhibitor produced by Streptomyces strain N-12, with IC50s of 62 nM and 250 nM for PKC and protein kinase A (PKA), respectively. UCN-02 (7-epi-Hydroxystaurosporine) displays cytotoxic effect on the growth of HeLa S3 cells[1][2].

Product Specifications

CAS Number

[121569-61-7]

Product Name Alternative

7-epi-Hydroxystaurosporine

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PKA; PKC

Type

Natural Products

Related Pathways

Epigenetics; Stem Cell/Wnt; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ucn-02.html

Purity

98.0

Solubility

10 mM in DMSO

Smiles

C[C@]12N3C4=C(C5=CC=CC=C53)C([C@@H](NC6=O)O)=C6C7=C4N([C@](C[C@H]([C@H]2OC)NC)([H])O1)C8=CC=CC=C78

Molecular Formula

C28H26N4O4

Molecular Weight

482.53

Precautions

H302, H315, H319, H335

References & Citations

[1]Takahashi I, et al. UCN-01 and UCN-02, new selective inhibitors of protein kinase C. I. Screening, producing organism and fermentation. J Antibiot (Tokyo) . 1989 Apr;42 (4) :564-70.|[2]Takahashi I, et al. UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physico-chemical properties, structural determination and biological activities. J Antibiot (Tokyo) . 1989 Apr;42 (4) :571-6.