GW3965
Product Specifications
UNSPSC Description
GW3965 is a potent, selective liver X receptor (LXR) agonist with EC50s of 190 nM and 30 nM for hLXRα and hLXRβ, respectively[1][2][3].
Target Antigen
LXR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/GW3965.html
Solubility
10 mM in DMSO
Smiles
ClC1=C(C(F)(F)F)C=CC=C1CN(CC(C2=CC=CC=C2)C3=CC=CC=C3)CCCOC4=CC(CC(O)=O)=CC=C4
Molecular Weight
582.05
References & Citations
[1]Mitro, Nico., et al. LXR and TSPO as new therapeutic targets to increase the levels of neuroactive steroids in the central nervous system of diabetic animals. Neurochemistry International (2012), 60(6), 616-621.|[2]Guo, Deliang., et al. An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR-Dependent Pathway. Cancer Discovery (2011), 1(5), 442-456.|[3]Spyridon, Michael., et al. LXR as a novel antithrombotic target. Blood (2011), 117(21), 5751-5761.Am J Physiol Endocrinol Metab. 2019 Jun 1;316(6):E1136-E1145. |Bioconjug Chem. 2015 Nov 18;26(11):2216-22. |Cancer Lett. 2023 May 5;216208.|Cell Death Differ. 2020 Aug;27(8):2433-2450. |J Am Heart Assoc. 2021 May 8;e018455.|J Ethnopharmacol. 2023 May 24;315:116684.|Sci Adv. 15 Jul 2022.|Theranostics. 2020 Jul 11;10(19):8834-8850. |Vet Microbiol. 2024 Jan, 288, 109948.|bioRxiv. 2023 Mar 10.|Radboud University Nijmegen. 2021 Mar.|Viruses. 2022, 14(3), 514.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-10627/GW3965-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-10627/
Clinical Information
No Development Reported
CAS Number
405911-09-3
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