LYN-1604 (hydrochloride)
Product Specifications
UNSPSC Description
LYN-1604 hydrochloride is a potent UNC-51-like kinase 1 (ULK1) activator (EC50=18.94 nM) for the research of triple negative breast cancer (TNBC)[1].
Target Antigen
Apoptosis; Autophagy; ULK
Type
Reference compound
Related Pathways
Apoptosis;Autophagy
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/LYN-1604_hydrochloride.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
ClC1=CC=C(C(CN2CCN(C(CN(CC(C)C)CC(C)C)=O)CC2)OCC3=CC=C(C=CC=C4)C4=C3)C(Cl)=C1.[H]Cl
Molecular Weight
621.08
References & Citations
[1]Zhang L, et al. Discovery of a small molecule targeting ULK1-modulated cell death of triple negative breast cancer in vitro and in vivo. Chem Sci. 2017 Apr 1;8(4):2687-2701.Biochem J. 2019 Mar 12;476(5):875-887.|Cell Signal. 2024 Mar 11:118:111136.|Oxid Med Cell Longev. 15 Nov 2021.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-101923A/LYN-1604-hydrochloride-DataSheet-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2216753-86-3
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