Senazodan

Senazodan (MCI 154) is a Ca2+ sensitiser, and also shows inhibition effect on PDE III[1][2].

Product Specifications

CAS Number

[98326-32-0]

Product Name Alternative

MCI 154

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Senazodan.html

Solubility

DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C)

Smiles

O=C1CCC(C2=CC=C(NC3=CC=NC=C3)C=C2)=NN1

Molecular Formula

C15H14N4O

Molecular Weight

266.30

References & Citations

[1]Lehtonen LA, et al. Pharmacokinetics and pharmacodynamics of intravenous inotropic agents. Clin Pharmacokinet. 2004;43 (3) :187-203.|[2]Erhardt L. An emerging role for calcium sensitisation in the treatment of heart failure. Expert Opin Investig Drugs. 2005 Jun;14 (6) :659-70.|[3]Yang G, et al. Effects of MCI-154 on vascular reactivity and its mechanisms after hemorrhagic shock in rats. J Cardiovasc Pharmacol. 2006;47 (6) :751-757.|[4]Ming MJ, et al. Effects of MCI-154, a calcium sensitizer, on cardiac dysfunction in endotoxic shock in rabbits. Shock. 2000;13 (6) :459-463.