(±) -Fabesetron (hydrochloride)

(±) -Fabesetron hydrochloride ((±) -FK1052) is the racemate of Fabesetron hydrochloride, which is a potent 5-HT3 and 5-HT4 receptor dual antagonist[1].

Product Specifications

CAS Number

[129299-81-6]

Product Name Alternative

(±) -FK1052

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/FK_1052_(hydrochloride).html

Solubility

10 mM in DMSO

Smiles

O=C1C(CC2=C(C)N=CN2)CCC(N31)=C(C)C4=C3C=CC=C4.[H]Cl

Molecular Formula

C18H20ClN3O

Molecular Weight

329.82

References & Citations

[1]Kadowaki M, et al. Effect of FK1052, a potent 5-hydroxytryptamine3 and 5-hydroxytryptamine4 receptor dual antagonist, on colonic function in vivo. J Pharmacol Exp Ther. 1993 Jul;266 (1) :74-80.|[2]Yamakuni H, et al. Probable involvement of the 5-hydroxytryptamine (4) receptor in methotrexate-induced delayed emesis in dogs. J Pharmacol Exp Ther. 2000 Mar;292 (3) :1002-7.