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Anti-Phospho-p56Dok-2 (Tyr299) Antibody

Boster Bio Anti-Phospho-p56Dok-2 (Tyr299) Antibody (Catalog # P07956) . Tested in WB, IHC, IF applications. This antibody reacts with Human.

Product Specifications

Background

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation <br> <br> Feng Cong, et, al. (1999) Mol. Cell. Biol ; 19: 8314 - 8325. <br> Serge Lemay, et, al. (2000) Mol. Cell. Biol ; 20: 2743 - 2754. <br> Ute Schaeper, et, al.(2000) J. Cell Biol ; 149: 1419. <br> Miyuki Honma, et, al. (2006) Genes Cells; 11: 143 - 151.

Synonyms

Docking protein 2; Downstream of tyrosine kinase 2; p56 (dok-2) ; DOK2

Gene Name

DOK2

UniProt

O60496

Host

Rabbit

Reactivity

Human

Immunogen

Peptide sequence around phosphorylation site of tyrosine 299 (G-E-Y (p) -A-V) derived from Human p56Dok-2.

Clonality

Polyclonal

Tissue Specificity

Highly expressed in peripheral blood leukocytes, lymph nodes and spleen. Lower expression in thymus, bone marrow and fetal liver. .

Applications

WB, IHC, IF

Field of Research

Adapters, Cancer, Cytoplasmic, MAPK Pathway, Protein Phosphorylation, Ser/Thr Kinases, Signal Transduction, Tyrosine Kinases

Purification

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

Concentration

1 mg/ml

Form

Liquid

Function

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity) . .

Molecular Weight

45379 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=P07956

Product MSDS

https://www.bosterbio.com/msds?sku=P07956

Other Gene Names

Docking protein 2

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