Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-Phospho-Smad2 (S255) Rabbit Monoclonal Antibody

Boster Bio Anti-Phospho-Smad2 (S255) Rabbit Monoclonal Antibody catalog # P00090. Tested in WB, IHC, IP applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Phospho Site

S255

Synonyms

Mothers against decapentaplegic homolog 2; MAD homolog 2; Mothers against DPP homolog 2; JV18-1; Mad-related protein 2; hMAD-2; SMAD family member 2; SMAD 2; Smad2; hSMAD2; SMAD2; MADH2, MADR2

Gene Name

Mothers against decapentaplegic homolog 2

UniProt

Q15796

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthesized peptide derived from human Smad2

Clonality

Monoclonal

Clone

Clone: HBE-19

Tissue Specificity

Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta. .

Applications

WB, IHC, IP

Field of Research

Cancer, Cytoplasmic, Epigenetics and Nuclear Signaling, Growth Factors, Nuclear Signaling, Nuclear Signaling Pathways, Signal Transduction, Signaling Pathway, Stem Cells, TGF Beta

Purification

Affinity-chromatography

Concentration

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=P00090

Product MSDS

https://www.bosterbio.com/msds?sku=P00090

Fragment

Rabbit IgG

Applications Notes

WB 1:1000-1:2000<br>IHC 1:50-1:200<br>IP 1:50

Other Gene Names

SMAD2

Subcellular Location

Cytoplasm. Nucleus. Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4. On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1.
Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Cytotoxic T-lymphocyte protein 4/CTLA4/CD152(Fc fusion)
E21-I31 10ug

Cytotoxic T-lymphocyte protein 4/CTLA4/CD152(Fc fusion)

Ask
View Details
APBA2BP CRISPR/Cas9 KO Plasmid (m)
sc-425321 20 µg

APBA2BP CRISPR/Cas9 KO Plasmid (m)

Ask
View Details
Dtnbp1 (NM_025772) Mouse Tagged ORF Clone Lentiviral Particle
MR205351L3V 200 µL

Dtnbp1 (NM_025772) Mouse Tagged ORF Clone Lentiviral Particle

Ask
View Details
2-Dodecylfuran
HY-169498 Inquire

2-Dodecylfuran

Ask
View Details