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Anti-Phospho-SMC1 (S957) Monoclonal Antibody

Boster Bio Anti-Phospho-SMC1 (S957) Monoclonal Antibody catalog # MP02148. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human.

Product Specifications

Phospho Site

S957

Synonyms

Red fluorescent protein eqFP611; GFP-like chromoprotein

Gene Name

Red fluorescent protein eqFP611

UniProt

Q14683

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human Phospho-SMC1 (S957) Structural maintenance of chromosomes 1 (SMC1) protein is a chromosomal protein member of the cohesin complex that enables sister chromatid cohesion and plays a role in DNA repair . ATM/NBS1-dependent phosphorylation of SMC1 occurs at Ser957 and Ser966 in response to ionizing radiation (IR) as part of the intra-S-phase DNA damage checkpoint. SMC1 phosphorylation is ATM-independent in cells subjected to other forms of DNA damage, including UV light and hydroxyurea treatment.

Clonality

Monoclonal

Clone

Clone: FCI-19

Tissue Specificity

Highly and selectively expressed by undifferentiated rather than differentiated embryonic stem cells (ESC) . Levels rapidly diminish as soon as ESC's differentiate (at protein levels) . Expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinoma. .

Applications

WB, IHC, ICC, IF

Field of Research

Cell Biology, Cell Cycle, Cell Division

Purification

Affinity-chromatography

Concentration

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

Pigment protein. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=MP02148

Product MSDS

https://www.bosterbio.com/msds?sku=MP02148

Fragment

Rabbit IgG

Applications Notes

WB 1:500-1:2000<br>IHC 1:50-1:200<br>ICC/IF 1:50-1:200

Other Gene Names

SMC1A

Subcellular Location

Lateral cell membrane ; Single-pass type I membrane protein . Cell junction, tight junction . Colocalizes with CLDN7 at the lateral cell membrane and tight junction. .
Curated Selection

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