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Anti-Human IgM IGHM Rabbit Monoclonal Antibody

Boster Bio Anti-Human IgM IGHM Rabbit Monoclonal Antibody catalog # M07469-1. Tested in WB, IHC, IP applications. This antibody reacts with Human.

Product Specifications

Synonyms

Ig mu chain C region; IGHM

Gene Name

Ig mu chain C region

UniProt

P01871

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human Human IgM

Clonality

Monoclonal

Clone

Clone: AOCG-9

Tissue Specificity

Expressed by all types of trophoblasts as early as 9 weeks of development. Specific for trophoblastic cells except for amniotic epithelium. In adult tissues, the expression is limited to a few epithelial cell types but is found on a variety of carcinoma.

Applications

WB, IHC, IP

Field of Research

RNA Polymerase, Transcription

Purification

Affinity-chromatography

Concentration

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Reconstitution

Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Function

IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions. The membrane- bound form is found in the majority of normal B-cells alongside with IgD. Membrane-bound IgM induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. It may cause death of cells by apoptosis. It is also found in soluble form, which represents about 30% of the total serum immunoglobulins where it is found almost exclusively as a homopentamer. After the antigen binds to the B-cell receptor, the secreted form is secreted in large amounts. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=M07469-1

Product MSDS

https://www.bosterbio.com/msds?sku=M07469-1

Fragment

Rabbit IgG

Applications Notes

WB 1:500-1:2000<br>IHC 1:50-1:200<br>IP 1:50

Other Gene Names

IGHM

Subcellular Location

Isoform 1: Secreted. During differentiation, B-lymphocytes switch from expression of membrane- bound IgM to secretion of IgM.

Protein Name

T-cell surface glycoprotein CD3 zeta chain

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