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Anti-TAX1BP3 Monoclonal Antibody

Boster Bio Anti-TAX1BP3 Monoclonal Antibody catalog # M05588. Tested in WB, IHC, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Drebrin; Developmentally-regulated brain protein; DBN1; D0S117E

Gene Name

Drebrin

UniProt

O14907

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthesized peptide derived from human TAX1BP3 May play a role in the Rho signaling pathway. May act as an inhibitor of the Wnt signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6.

Clonality

Monoclonal

Clone

Clone: ADDC-20

Tissue Specificity

Brain neurons. Also found in the heart, placenta, skeletal muscle, kidney and pancreas. Expressed in peripheral blood lymphocytes, including T-cells (at protein level) . .

Applications

WB, IHC, Flow Cytometry

Field of Research

Cytoplasmic, Developmental Families, Domain Families, Epigenetics and Nuclear Signaling, G Protein Signaling, Nuclear, Regulators, Signal Transduction, Signaling Pathway, Signaling Pathways, Small G Proteins, Stem Cells, Transcription

Purification

Affinity-chromatography

Concentration

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Reconstitution

Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Function

Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites. Required for actin polymerization at immunological synapses (IS) and for CXCR4 recruitment to IS. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=M05588

Product MSDS

https://www.bosterbio.com/msds?sku=M05588

Fragment

Rabbit IgG

Applications Notes

WB 1:500-1:2000<br>IHC 1:50-1:200<br>FC 1:70

Other Gene Names

TAX1BP3

Subcellular Location

Cytoplasm . Cytoplasm, cell cortex . Cell junction . Cell projection . Cell projection, growth cone . In the absence of antigen, evenly distributed throughout subcortical regions of the T-cell membrane and cytoplasm. In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation clusters (SMAC) (PubMed:20215400) . Colocalized with DBN1, RUFY3 and F-actin at the transitional domain of the axonal growth cone (By similarity) . .

Protein Name

T-cell surface glycoprotein CD3 zeta chain

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